This free, standards-based, online publication, developed for middle school science teachers, explores the body. Other sections in this publication provide lessons and activities for students on topics of structure and function of cells, tissues, organs, and organ systems as well as information about comparative anatomy and diversity. In this way, students may study body systems from two perspectives: within and between species in alignment with the diversity and adaptation aspect of the NSES Life Science Standard. In addition, new technologies associated with human body systems are explored. As always, new technologies come with social and personal implications, also for investigation in this publication and aligned with the NSES.