More anhydrous ammonia is used as fertilizer in North Dakota than any other nitrogen fertilizer source. Anhydrous ammonia is classified as a hazardous substance. Most accidents with anhydrous ammonia are due to uncontrolled releases. Few problems occur when the ammonia is being handled and applied as intended. Most uncontrolled releases are due to improper procedures, careless or untrained workers, or faulty equipment. Protective equipment is required by law to be available where anhydrous ammonia is handled or applied. Wearing protective equipment greatly reduces the chance of injury from an ammonia release. Countless tons of anhydrous ammonia are applied every crop year without problems; safe procedures and good-quality equipment do work.

Anhydrous ammonia has the potential to be one of the most dangerous chemicals used in agriculture today. It is used and stored under high pressures, which requires specially designed and well-maintained equipment. Those who work with anhydrous ammonia must be trained to follow exact procedures in handling it.