In its efforts to provide public health guidance to state and local health departments, other federal agencies, health professionals, and the public on the health effects of environmental pollutants, the Agency for Toxic Substances and Disease Registry (ATSDR) relies on the latest advances in computational toxicology. Housed within the Division of Toxicology and Environmental Medicine, the Computational Toxicology Laboratory (CompTox Lab) supports the agency mission by developing and applying state-of-the-art computational toxicology methods such as physiologically based pharmacokinetic/pharmacodynamic (PBPK/PD) modeling, quantitative structure-activity relationship (QSAR) methods, and benchmark dose (BMD) models. The developed PBPK, QSAR and BMD models are then implemented to determine and characterize risks from exposure to hazardous substances.