Skip Navigation

the Environmental and Energy Resources Library

Home Browse Resources Get Recommendations Forums About Help Advanced Search

Proximity to Pollution Sources and Risk of Amphibian Limb Malformation

“The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem."

Cumulative Rating: (not yet rated)
Date Of Record Release 2009-02-22 17:35:01
Description “The cause of limb deformities in wild amphibian populations remains unclear, even though the apparent increase in prevalence of this condition may have implications for human health. Few studies have simultaneously assessed the effect of multiple exposures on the risk of limb deformities. In a cross-sectional survey of 5,264 hylid and ranid metamorphs in 42 Vermont wetlands, we assessed independent risk factors for nontraumatic limb malformation. The rate of nontraumatic limb malformation varied by location from 0 to 10.2%. Analysis of a subsample did not demonstrate any evidence of infection with the parasite Ribeiroia. We used geographic information system (GIS) land-use/land-cover data to validate field observations of land use in the proximity of study wetlands. In a multiple logistic regression model that included land use as well as developmental stage, genus, and water-quality measures, proximity to agricultural land use was associated with an increased risk of limb malformation (odds ratio = 2.26; 95% confidence interval, 1.42-3.58; p < 0.001). The overall discriminant power of the statistical model was high (C = 0.79). These findings from one of the largest systematic surveys to date provide support for the role of chemical toxicants in the development of amphibian limb malformation and demonstrate the value of an epidemiologic approach to this problem."
Classification
Resource Type
Format
Subject
Source Yale Occupational and Environmental Medicine Program
Selector Bates
Date Of Record Creation 2009-02-22 17:29:03
Education Level
Date Last Modified 2009-02-22 17:51:08
Creator B Taylor, D Skelly, LK Demarchis, MD Slade, D Galusha, PM Rabinowitz
Language English
Date Record Checked: 2009-02-22 00:00:00 (W3C-DTF)

Log In:





Mission
EERL's mission is to be the best possible online collection of environmental and energy sustainability resources for community college educators and for their students. The resources are also available for practitioners and the public.

EERL & ATEEC
EERL is a product of a community college-based National Science Foundation Center, the Advanced Technology Environmental and Energy Center (ATEEC), and its partners.

Contact ATEEC 563.441.4087 or by email ateec@eicc.edu