Certain U.S. drinking water regulations—in particular the Stage 1 and 2 Disinfectants/Disinfection By-Products Rules and the Long-Term 1 and 2 Enhanced Surface Water Treatment Rules—have the potential to conflict with each other, as well as with other regulations such as the Lead and Copper Rule and the Total Coliform Rule. This means that small system operators cannot simply comply with these mandates individually, but must consider how changing their treatment process to meet one rule might affect compliance with other rules. This Tech Brief provides information and strategies to effectively comply with those regulations that are most likely to conflict with one another.